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Persistent genital arousal disorder PGAD is characterized by unrelenting, spontaneous, and uncontainable genital arousal, mostly in females. A woman with PGAD can experience spontaneous orgasms that do not resolve arousal. PGAD can lead to ongoing physical pain, stress , and psychological difficulties due to an inability to carry out everyday tasks. The condition can affect women of all ages. Experts have not clinically confirmed the incidence of PGAD, as many people with the condition feel too embarrassed or ashamed to seek medical help.
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Persistent genital arousal disorder (PGAD): Treatment and causes

Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. Persistent genital arousal disorder PGAD in women is associated with feelings of persistent, spontaneous, intrusive, unrelenting, and unwanted physical arousal in the absence of conscious thoughts of sexual desire or sexual interest. Written consent was obtained from the patient. Abatement of lifelong PGAD symptoms occurred within approximately two weeks each time varenicline treatment was initiated. PGAD symptoms returned in approximately 2 weeks each time treatment was suspended. Its unique pharmacological action stimulates a small amount of brain dopamine release while antagonizing the ability of nicotine to stimulate much larger dopamine release.
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A tic is a nonvoluntary body movement or vocal sound that is made repeatedly, rapidly, and suddenly. It has a stereotyped but nonrhythmic character. The child or adolescent with a tic experiences it as irresistible but can suppress the movement or noise for a period of time. Tics are categorized as motor or vocal, and as simple or complex.
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